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Tri Sugar Shield from Life Extension

60 vegetarian capsules / 30-day supply

RECOMMENDED USE: Take one (1) capsule twice daily immediately before the heaviest carbohydrate or sugar containing meals/drinks, or as recommended by a healthcare practitioner.

Available online only.
You watch your diet and exercise, yet your blood sugar levels can still rise as you age. And to counteract the problem you have to deal with a number of issues. Now you can effectively address this issue with a multi-pronged approach. Tri Sugar Shield® provides three plant-derived nutrients (sorghum bran extract, white mulberry leaf extract, and phloridzin) that work together to provide optimal support for healthy glucose metabolism.

Benefits at a Glance

Supports the natural balance of key glucose pathways
May balance the rate of sugar manufacture in the liver (gluconeogenesis)
Promotes insulin sensitivity
May inhibit glucose absorption by decreasing the activity of sugar digesting enzymes
May diminish glucose reabsorption from the kidneys
Supports the natural balance of key glucose pathways

Blood sugar levels can rise due to a number of factors including excess gluconeogenesis whereby the liver produces glucose from protein.1-3 Another issue is the rapid conversion of any starch, including whole grains, into glucose.4,5 The result is that even health-conscious people can experience higher-than-desired blood sugar levels as they age.

Tri Sugar Shield® is a unique formulation that improves glucose metabolism through several different pathways, including balancing the rate of sugar manufacture in the liver,6 promoting insulin sensitivity,7,8 decreasing the activity of sugar digesting enzymes in the gut,9-11 and by targeting carrier proteins in the kidney that diminishes glucose reabsorption into the circulation.12-15

Sorghum Bran Extract Modulates Four Mechanisms

Sorghum has long been cultivated in Asia (and now is grown in Africa, India, China, Australia, and the USA) and helps maintain healthy blood sugar levels, among those in the normal range, by modulating four different mechanisms:

Balances the rate of sugar manufacture in the liver (gluconeogenesis).6
Promotes insulin sensitivity.7
Regulates PPAR-gamma, a metabolic thermostat supporting glucose metabolism. 7,16,17
Regulates the enzyme alpha-amylase, which in turn maintains the release of sugar found in starch.9,18,19
Mulberry Leaf Extract Controls Three Mechanisms

Mulberry leaf has been used in Chinese traditional medicine for centuries. Mulberry leaf extract targets three different mechanisms:

Targets the alpha-glucosidase enzyme to regulate conversion of starch into glucose.10,11,20,21
Supports glucose transporter GLUT4 that moves glucose out of the bloodstream and into muscle and liver cells.12,22
Promotes insulin sensitivity.8
Phloridzin Impacts Kidney Reabsorption of Sugar

Phloridzin is a natural polyphenol found predominantly in apples.23 Phloridzin helps maintain healthy blood sugar levels, among those in the normal range by:

Targeting carrier protein SGLT1, in turn helping to block the absorption of glucose into the bloodstream.13,24
Targeting carrier protein SGLT2, in turn supporting glucose elimination via urine.14,15
By targeting all of these diverse glucose pathways, Tri Sugar Shield® delivers broad-spectrum support to help naturally stabilize already healthy glucose levels.

Supplement Facts
Serving Size 1 vegetarian capsule
Amount Per Serving
Sorghum bran (Sorghum bicolor) extract [providing 270 mg proanthocyanidins] 300 mg
White mulberry extract (leaf) [providing 7.5 mg 1-deoxynojirimycin] 150 mg
Phloridzin [from apple extract (root bark)] 50 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, maltodextrin, silica, stearic acid.



Croat Med J. 2006 October; 47(5): 709-13.
Int J Vitam Nutr Res. 2011 Mar;81(2-3):101-7.
PLoS One. 2013;8(1):e54011.
J Biol Chem. 2001 Sep 21;276(38):36000-7.
J Nutr. 1995 Jun;125(6):1430-7.
Nutr Metab (Lond). 2012;9(1):106.
Nutr Res Pract. 2012 Aug;6(4):322-7.
J Med Food. 2011 Jul-Aug;14(7-8):799-807.
Am J Clin Nutr. 2006 Sep;84(3):551-5.
J Agric Food Chem. 2007 Jul 11;55(14):5869-74.
J Agric Food Chem. 2009 Jun 10;57(11):4651-6.
Nat Rev Drug Discov. 2010 Jul;9(7):551-9.
Mol Biol Rep. 2012 May;39(5):5299-306.
Available at:­article/461349. Accessed January 16, 2014.
J Med Food.2011 Jul-Aug;14(7-8):799-807.
Vasc Health Risk Manag. 2008 Dec; 4(6): 1189–1195.
J Nat Med. 2008 Jan;62(1):63-6.
Cell Metab. 2007 Apr;5(4):237-52.
Phytochemistry. 2010 Jun;71(8-9):838-43.
Diabetes. 2012 Jan;61(1):187-96.

5 reviews for Life Extension Tri Sugar Shield

  1. DEBRA

    I would try this product again.
    This is a great product to try to reach A1C goals.

  2. ML

    I’ve tried some of the other sugar related products but this is by far the easiest to use. You can take it immediately before eating which eliminates the need to remember 30 minutes before (if at all!) you eat.

  3. Claudia

    I maintain an ongoing supply of this supplement
    I take Tri-Sugar Shield with both breakfast and dinner. I am in my mid-sixties and extremely health conscious. I exercise and am extremely careful of everything I eat and drink and how it will potentially affect my well being. I believe this supplement is a beneficial addition to my health regime.

  4. TK

    Very Impressed
    This product lowered my HA1C from 10.94 to 7.4 in one month. I used to to supplement my medications and will wait until my doctor feels that it is safe to take alone. Great results thus far.

  5. steve

    Absolutely amazing supplement
    This is a very effective supplement, I would highly recommend that anyone thinking about using this supplement, that you read the article that appeared in the Feb 2014 Life Extension magazine. The scientific research that went into the R and D of this supplement was quite extensive. I have been using Tri Sugar Shield since 2014 and I am extremely satisfied with its glucose lowering ability. I have tried several other products and none compares to the effectiveness of Tri Sugar Shield. My numbers are now consistently within the normal range without any side effects. I would highly recommend this product to anyone seeking similiar results.

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